Mitophagy Regulation in Skeletal Muscle: Effect of Endurance Exercise and Age

Effect of endurance exercise on myosin heavy chain gene regulation in human skeletal muscle.

The purpose of this study was to determine the effect of endurance-oriented exercise on myosin heavy chain (MHC) isoform regulation in human skeletal muscle. Exercise consisted of 1 h of cycle ergometer work per day at 75% maximal oxygen consumption for seven consecutive days. Muscle was obtained before the first bout of exercise, 3 h after the first bout of exercise, and before and 3 h after t...

Skeletal Muscle Following Intense Endurance Exercise

Protein-leucine Ingestion Activates a Regenerative Inflammo-Myogenic Transcriptome in 1 Skeletal Muscle Following Intense Endurance Exercise 2 3 David S. Rowlands, Andre R. Nelson, Frederic Raymond, Sylviane Metairon, Robert 4 Mansourian, Jim Clarke, Trent Stellingwerff, Stuart M. Phillips 5 6 School of Sport and Exercise and Institute of Food Nutrition, and Human Health, Massey University, 7 W...

Age-Associated Changes in Skeletal Muscle Regeneration: Effect of Exercise

Aim of the present short review is to provide a comprehensive update on age-associated skeletal muscle damage, regeneration, and effect of endurance and resistance type of exercise training on muscle regeneration. Decrease in muscle quantity and quality leads to disability in the aging population. The degradation rate of muscle proteins during aging increased about two times, and muscle strengt...

Characteristics and Adaptation of Skeletal Muscle to Endurance Exercise

Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal

OBJECTIVE We tested the hypothesis that skeletal muscle of endurance-trained male runners would exhibit elevated autophagy and mitophagy markers, which would be associated with greater metabolic flexibility following a high-fat meal (HFM). METHODS Muscle biopsies were collected to determine differences in autophagy and mitophagy protein markers and metabolic flexibility under fasting conditio...